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The SURMOUNT-1 trial demonstrated significant weight loss, with patients losing approximately 15-21% of their body weight at the 15 mg dose over 72 weeks, depending on the statistical method used

In metabolic regulation, Scrophularia -containing formulations (e.g., Clean-DM1) activate IRS/PI3K/AKT and AMPK signaling pathways, thereby improving insulin resistance and correcting glucose-lipid metabolic dysfunction (138)

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At least 5% of ASD cases are caused by single nucleotide polymorphisms (SNPs) in genes such as NLGN3, NLGN4, NRXN1, MECP2, SHANK3, FMR1, and UBE3A, with about 10% of these variants being copy number variations (CNVs) that disrupt protein-coding sequences (6163)